Maneb and Paraquat-Mediated Neurotoxicity: Involvement of Peroxiredoxin/Thioredoxin System
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چکیده
منابع مشابه
Maneb and paraquat-mediated neurotoxicity: involvement of peroxiredoxin/thioredoxin system.
Epidemiological and in vivo studies have demonstrated that exposure to the pesticides paraquat (PQ) and maneb (MB) increase the risk of developing Parkinson's disease (PD) and cause dopaminergic cell loss, respectively. PQ is a well-recognized cause of oxidative toxicity; therefore, the purpose of this study was to determine if MB potentiates oxidative stress caused by PQ, thus providing a mech...
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A combination of the herbicide paraquat (PQ) and fungicide maneb (MB) has been linked to Parkinson's disease. Previous studies show that this involves an additive toxicity with at least two different mechanisms. However, detailed understanding of mixtures is often difficult to elucidate because of the multiple ways by which toxic agents can interact. In the present study, we used a combination ...
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Paraquat [(2 MP*), 1,l '-dimethyl-4,4'-bipyridine dication] is a herbicide used for weed control in various crops or for desiccation of marihuana plants. Accidental and suicidal poisonings with paraquat are not uncommon (1). Several analytical methods have been published for the determination of 2 MP' in human body fluids, postmortem tissues, air, and foods consumed by humans. Analysis of 2 MP'...
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Experimental evidence supporting 1,1'-dimethyl-4,4'-bipyridinium [paraquat (PQ)] as a risk factor for Parkinson's disease (PD) is equivocal. Other agricultural chemicals, including dithiocarbamate fungicides such as manganese ethylenebisdithiocarbamate [maneb (MB)], are widely used in the same geographical regions as paraquat and also impact dopamine systems, suggesting that mixtures may be mor...
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Oxidative stress has been implicated in the pathogenesis of Parkinson disease based on its role in the cascade of biochemical changes that lead to dopaminergic neuronal death. This study analyzed the role of oxidative stress as a mechanism of the dopaminergic neurotoxicity produced by the combined paraquat and maneb model of the Parkinson disease phenotype. Transgenic mice overexpressing either...
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ژورنال
عنوان ژورنال: Toxicological Sciences
سال: 2011
ISSN: 1096-6080,1096-0929
DOI: 10.1093/toxsci/kfr058